Figure 7
From: Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy
The long-term repopulation of escape cells following cisplatin (CDDP)-paclitaxel (PTX) cytotoxic therapy is abrogated or limited by mifepristone (MF) in OV2008 (A), A2780 (B), IGROV-1 (C) and SK-OV-3 (D) cells. Cells were exposed to 20 μM CDDP for 1 h, 100 nM PTX for 3 h and either chronically exposed or not exposed to 10 μM MF. Number of cells was assessed after one, two or three weeks of initial treatment. The dashed lines represent the relative number of cells originally plated before subjecting the culture to the various treatment schedules.