Figure 9From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1 BRCA1 mRNA and protein expression are modulated by DcR3. Real time reverse transcriptase PCR (A. means of triplicate samples by RT-PCR and B. examples of individual melt curves) and Western Blot (C) for BRCA1 demonstrate that the differential changes in BRCA1 expression between SKOV-3/OVCAR-3 and CaOV-3 cells exposed to DcR3 are in line with the changes seen in platinum responsiveness from the same DcR3 treated cultures.Back to article page