Figure 1

Systemic therapy according consensus giudelines (St. Gallen). EIC – extensive intraductal component, WBRT – whole breast radiotherapy, SNB – sentinel node-biopsy, BCS – breast conserving surgery L1 – lymphangio invasion *modifications according to local protocols and national guidelines; **with reference to national guidelines a re-resection should be performed in presence of positive resection margins (e.g. <1cm in Germany).