Gene Varianta | Control | Overall (n = 372) | Oropharynx (n = 184) | Non-oropharynx (n = 188) | |||
---|---|---|---|---|---|---|---|
n = 315 (%) | Patients (%) | ORb (95%CI) | Patients (%) | ORb (95%CI) | Patients (%) | ORb (95%CI) | |
NOXA rs9957673 | Â | Â | Â | Â | Â | Â | Â |
 CC | 216 (68.6) | 246 (66.1) | 1.0 | 118 (64.1) | 1.0 | 128 (68.1) | 1.0 |
 CT | 95 (30.2) | 115 (30.9) | 1.0 (0.7-1.4) | 60 (32.6) | 1.1 (0.7-1.7) | 55 (29.3) | 1.1 (0.9-1.6) |
 TT | 4 (1.3) | 11 (3.0) | 2.3 (0.7-7.4) | 6 (3.3) | 1.9 (0.4-8.1) | 5 (2.7) | 2.0 (0.5-8.3) |
 |  |  | P trend =0.300 |  | P trend = 0.180 |  | P trend = 0.689 |
CT + TT | 99 (31.4) | 126 (33.9) | 1.1 (0.8-1.5) | 66 (35.9) | 1.1 (0.7-1.7) | 60 (31.9) | 1.1 (0.7-1.6) |
NOXA rs4558496 | Â | Â | Â | Â | Â | Â | Â |
 TT | 216 (68.6) | 253 (69.1) | 1.0 | 121 (65.8) | 1.0 | 136 (72.3) | 1.0 |
 TG | 85 (27.5) | 107 (29.3) | 1.0 (0.7-1.5) | 61 (33.2) | 1.23 (0.8-1.9) | 48 (25.5) | 0.9 (0.6-1.3) |
 GG | 14 (4.3) | 6 (1.6) | 0.4 (0.2-1.1) | 2 (1.1) | 0.34 (0.1-1.6) | 4 (2.1) | 0.4 (0.1-1.4) |
 |  |  | P trend =0.411 |  | P trend = 0.913 |  | P trend = 0.224 |
 TG + GG | 99 (31.4) | 115 (30.9) | 1.0 (0.7-1.3) | 63 (34.3) | 1.1 (0.7-1.7) | 52 (27.7) | 0.8 (0.5-1.2) |
MCL1 rs9803935 | Â | Â | Â | Â | Â | Â | Â |
 GG | 95 (30.2) | 127 (34.1) | 1.0 | 65 (35.3) | 1.0 | 62 (33.0) | 1.0 |
 GT | 157 (59.8) | 169 (45.4) | 0.8 (0.6-1.2) | 77 (41.9) | 0.8 (0.5-1.3) | 92 (48.9) | 0.9 (0.6-1.4) |
 TT | 63 (20.0) | 76 (20.4) | 0.9 (0.6-1.5) | 42 (22.8) | 1.1 (0.6-1.8) | 34 (18.1) | 0.9 (0.6-1.6) |
 |  |  | P trend =0.516 |  | P trend = 0.726 |  | P trend = 0.463 |
 GG + GT | 252 (80.0) | 296 (79.6) | 1.0 | 142 (77.2) | 1.0 | 154 (81.9) | 1.0 |
 TT | 63 (20.0) | 76 (20.4) | 1.0 (0.7-1.5) | 42 (22.8) | 1.2 (0.7-1.9) | 34 (18.1) | 1.0 (0.6-1.6) |
MCL1 rs3738485 | Â | Â | Â | Â | Â | Â | Â |
 GG | 93 (29.5) | 128 (34.4) | 1.0 | 65 (35.3) | 1.0 | 63 (33.5) | 1.0 |
 GC | 155 (49.2) | 168 (45.2) | 0.8 (0.6-1.2) | 77 (41.9) | 0.8 (0.5-1.3) | 91 (47.4) | 0.9 (0.6-1.3) |
 CC | 67 (21.3) | 76 (20.4) | 0.9 (0.6-1.3) | 42 (22.8) | 1.0 (0.6-1.7) | 34 (18.1) | 0.9 (0.5-1.5) |
 |  |  | P trend =0.298 |  | P trend = 0.528 |  | P trend = 0.271 |
 GG + GC | 248 (78.7) | 296 (79.6) | 1.0 | 142 (77.2) | 1.0 | 154 (81.9) | 1.0 |
 CC | 67 (21.3) | 76 (20.4) | 1.0 (0.7-1.4) | 42 (22.8) | 1.1 (0.7-1.8) | 34 (18.1) | 0.9 (0.6-1.5) |