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Table 5 Compared clinicalpathological features between 35 surgical HCC patients with multiple primary tumor and 140 HCC patients without extrahepatic tumor

From: Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

Characteristic

Multiple primary

tumor group (n=35)

Control group

(HCC-alone) (n=140)

Pvalue

Age (years) *

56.3±12.6

59.1±11.2

0.317

Gender (Female: Male)

5:30

30:115

0.616

HBsAg (Negative: Positive)

7:28

12:128

0.101

AFP level (<25: ≥25) (ng/ml)

17:18

44:96

0.057

GGT level (<50: ≥50) (U/ml)

11:24

53:87

0.480

Child-Pugh classification (A:B)

32:3

134:6

0.549

Tumor size (<5cm : ≥5cm)

12:23

40:100

0.508

Tumor number (Solitary: Multiply)

30:5

132:8

0.171

Vascular invasion (No: Yes)

32:3

131:9

0.940

Tumor capsule (No: Yes)

19:16

60:80

0.224

Cirrhosis (No: Yes)

8:27

23:117

0.373

Surgical margin (<2cm : ≥2cm)

20:15

57:83

0.080

TNM stage (I: II: III)

26:4:5

112:18:10

0.401

Complication (No: Yes)

6:29

14:126

0.373

  1. HCC: hepatocellular carcinoma, HBsAg: hepatitis B surface antigen, AFP: α-fetoprotein, GGT: gamma-glutamyltransferase, TNM: tumor-node-metastasis.
  2. * Mean ± Standard Deviation.
  3. Chi-square test for difference between proportions (except that of Age).
  4. T test for difference between means.