Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells

Table 1 Fold changes in ARCAP-E cells (combined vorinostat/genistein vs. DMSO) of critical genes involved in apoptosis, DNA damage checkpoint, and chromatin structure and remodeling

Symbol	Synonym	Fold Change	Network	Symbol	Synonym	Fold Change	Network
GZMB	Granzyme B	6.9	Apoptosis	CTNNB1	β-catenin	1.7	Apoptosis
TNFRSF6B	Decoy Receptor 3	4.8	Apoptosis	MTA2	---	1.7	Chromatin
BIRC3	c-IAP2	4.1	Apoptosis	CHEK2	RAD53	1.6	DNA Checkpoint
TNF	TNFα	3.9	Apoptosis	BUB1	---	1.6	DNA Checkpoint
DFFA	ICAD	3.8	Apoptosis	TGFB1I1	ARA55	−1.8	Apoptosis
BARD1	BRCA1 Associated	3.0	DNA Checkpoint	TNFSF10	TRAIL	−1.9	Apoptosis
MAD2L1	---	2.4	DNA Checkpoint	CREBBP	CBP	−2.1	Chromatin
HAT1	Histone Acetyltrans-ferase 1	2.4	Chromatin	SIRT1	SIR2L1	−2.1	Chromatin
GZMH	Granyme H	2.3	Apoptosis	ATM	TEL1	−2.2	DNA Checkpoint
AURKB	Aurora Kinase B	2.2	DNA Checkpoint	TNFRSF14	LIGHTR	−3.7	Apoptosis
BCL10	---	2.0	Apoptosis	BIRC7	Livin	−4.8	Apoptosis
BRCA1	---	1.9	DNA Checkpoint

ISSN: 1471-2407