Figure 5

Impact of the AR T105A 5'UTR variant. Luciferase reporter activities of pGL3 basic with the AR promoter (AR prom) and pGL3 promoter vector which contains the SV40 promoter (SV40 prom) together with either the wild-type (WT) or T105A mutant (MT) AR 5'UTR sequence in MCF7 and T47D cells. Data is shown relative to the respective empty vector ± the standard error of the mean (SEM) and was generated from three independent experiments. ***P = 0.0001.