Prognostic impact of mRNA levels of osteopontin splice variants in soft tissue sarcoma patients

BMC Cancer

Table 1 Clinical and histomorphological data

Parameter	Total (n = 124)	OPN-a mRNA expression		OPN-b mRNA expression		OPN-c mRNA expression
		low (n = 62)	high (n = 62)	low (n = 62)	high (n = 62)	low (n = 62)	high (n = 62)
Sex		P = 0.02		P = 0.10		P = 0.37
Male	56	35	21	33	23	31	25
Female	68	27	41	29	39	31	37
Histological subtype		P = 0.96		P = 0.17		P = 0.17
Liposarcoma	27	14	13	14	13	13	14
MFH/Fibrosarcoma	38	17	21	14	24	14	24
NS	15	8	7	9	6	9	6
RMS + LMS	29	15	14	14	15	15	14
other STS	15	8	7	11	4	11	4
Tumor grade		P = 0.03		P = 0.05		P = 0.03
I	16	6	10	6	10	4	12
II	70	42	28	42	28	42	28
III	37	13	24	14	23	16	21
Tumor stage		P = 0.37		P = 0.43		P = 0.33
I	15	7	8	7	8	5	10
II	57	33	24	33	24	33	24
III	40	18	22	17	23	19	21
IV	12	4	8	5	7	5	7
Tumor localization		P = 0.29		P = 0.26		P = 0.30
Extremities	79	37	42	37	42	36	43
Thorax	12	5	7	5	7	6	6
Head and neck	4	1	3	1	3	1	3
Abdominal	27	18	9	17	10	18	9
Other	2	1	1	2	0	1	1
Recurrence		P = 1.00		P = 1.00		P = 1.00
Yes	55	28	27	28	27	27	28
No	69	34	35	34	35	35	34
Lymph node status		P = 0.21		P = 0.21		P = 0.03
N0	118	61	57	61	57	62	56
N1	6	1	5	1	5	0	6
Distant metastases		P = 0.28		P = 0.88		P = 0.88
M0	45	25	20	23	22	23	2
M1	50	20	30	24	26	24	26
Evaluation not possible	3	2	1	2	1	2	1
Radiation		P = 1.00		P = 0.86		P = 0.86
Yes	58	29	29	30	28	30	28
No	66	33	33	32	34	32	34
Chemotherapy		P = 0.74		P = 0.74		P = 0.74
Yes	10	4	6	4	6	4	6
No	114	58	56	58	56	58	56

Abbreviations: MFH - malignant fibrous histiocytoma, NS - neurogenic sarcoma, RMS - rhabdomyosarcoma, LMS - leiomyosarcoma

ISSN: 1471-2407