Interleukin-10-819 promoter polymorphism in association with gastric cancer risk

BMC Cancer

Table 1 Study Characteristics of genotypes in gastric cancer cases and controls in the analysis of Interleukin-10-819 Promoter Genetic Polymorphisms

First author	Year of publication	Quality assessment scores	Genotyping method	Total sample size	Number of controls	Number of cases	Study location	Ethnic group	P values for HWE	Controls, genotypes(n)			All Cases, genotypes(n)
										CC	CT	TT	CC	CT	TT
Wu MS	2003	7	Direct sequencing	450	230	220	China	Asians	0.231397685	20	83	127	27	105	88
Savage SA^#	2004	5	ABI Genetic Analyzer	466	382	84	China	Asians	0.314869012	49	163	170	9	38	37
Alpízar-Alpízar W	2005	6	Pyrosequencing	90	45	45	Costa Rica	Latinos	0.08326454	18	24	3	25	16	4
Zambon CF^{^}	2005	5	TaqMan	773	644	129	Italy	Caucasians	0.696436614	353	245	46	70	42	17
Kamangar F^{#^¶}	2006	8	TaqMan	250	152	98	Finland	Caucasians	0.66272429	80	62	10	58	35	5
Sugimoto M^{#^*¶+}	2007	6.5	ASP	273	168	105	Japan	Asians	0.194224595	9	73	86	6	57	42
Crusius JB^{#^}	2008	8.5	ABI real-time PCR	1323	1094	229	European	Caucasians	0.02386503	636	378	80	145	72	12
Xiao H	2009	6	RFLP	844	624	220	China	Asians	0.718880427	69	283	272	20	100	100
Ko KP	2009	7	SNaPshot	409	326	83	Korea	Asians	0.038333741	37	121	168	11	33	39
Su SP	2010	6.5	RFLP	143	100	43	China	Asians	0.433216715	6	43	51	4	21	18
Liu J⁺	2011	6.5	RFLP	477	243	234	China	Asians	0.772829993	28	106	109	39	96	99

#Data of cardia-subtype gastric cancer were accessible; ^ Data of noncardia-subtype gastric cancer were accessible; * Data of sporadic diffuse-subtype gastric cancer were accessible; ¶ Data of intestinal-subtype gastric cancer were accessible. +Data of the status of Helicobacter pylori of gastric cancer were accessible. RFLP: Restriction fragment length polymorphisms; TaqMan: 5'nuclease polymerase chain reaction assays; Pyrosequencing: a method of DNA sequencing (determining the order of nucleotides in DNA) based on the "sequencing by synthesis" principle. It differs from Sanger sequencing, in that it relies on the detection of pyrophosphate release on nucleotide incorporation, rather than chain termination with dideoxynucleotides; Direct sequencing: method of methylation analysis using bisulfite-treated DNA utilized PCR and standard dideoxynucleotide DNA sequencing to directly determine the nucleotides resistant to bisulfite conversion; ASP: the allele specific primer-polymerase chain reaction (ASP-PCR) method; SNaPshot: the SNaPshot assay which provides detection of certain SNPs

ISSN: 1471-2407