Table 3 Details of genes over-expressed in K-Ras mutant tumours

ACOX2

Acyl-Coenzyme A oxidase 2, branched chain

3p14.3

4.9 E^-3

Lipid metabolism

ALDH2

Aldehyde dehydrogenase 2 family (mitochondrial)

12q24.2

9.8 E^-4

Alcohol metabolism

ALDH3B1

Aldehyde dehydrogenase 3 family, member B1

11q13

3.9 E^-3

Alcohol metabolism

AREG

Amphiregulin (schwannoma-derived growth factor)

4q13-q21

1.4 E^-4

Autocrine growth factor family member

CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

1q32

6.9 E^-4

Immune response, protection of cells from complement mediated damage

CLDN10

Claudin 10

13q31-q34

2.9 E^-3

Intercellular tight junctions

DGKD

Diacylglycerol kinase, delta 130kDa

2q37.1

1.0 E^-3

Intercellular signalling, cell growth.

EGR1

Early growth response 1

5q31.1

2.5 E^-3

Transcriptional regulation of genes involved in mitogenesis

MSLN

Mesothelin

16p13.3

4.61 E^-5

Possible role in cell adhesion

MST1R

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

3p21.3

4.5 E^-3

Cell motility, positive regulation of cell cycle

NPC2

Niemann-Pick disease, type C2

14q24.3

4.6 E^-4

Regulation of cholesterol transport and storage

NR4A1

Nuclear receptor subfamily 4, group A, member 1

12q13

6.2 E^-4

Transcription factor

PFDN1

Prefoldin subunit 1

5q31

1.5 E^-3

Cell cycle, transcription factor activity, protein folding

PTGS2

Prostaglandin-endoperoxide synthase 2 (cyclo-oxygenase 2)

1q25.2-q25.3

3.1 E^-3

Prostaglandin biosynthesis

ST3GAL5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

2p11.2

1.4 E^-3

Cell differentiation, cell proliferation, signal transduction.

TFPI2

Tissue factor pathway inhibitor 2

7q22

4.5 E^-4

Matrix remodelling, coagulation

UPP1

Uridine phosphorylase 1

7p12.3

1.0 E^-4

Nucleotide catabolism