Table 1 Regimens and drug doses of control and experimental arms
Setting | Treatment Arm | Regimens | Dose | Schedule | Reference |
|---|---|---|---|---|---|
Locally advanced | Control | Epirubicin | 75 mg/m², d 1 | Every 3 weeks for 4 cycles | de Matteis A, 2002 |
|  |  | Docetaxel | 80 mg/m², d 1 |  |  |
|  | Experimental | Epirubicin | 30 mg/m², dd 1-8-15 | Every 4 weeks for 3 cycles | Wenzel C, 2002 |
|  |  | Docetaxel | 35 mg/m², dd 1-8-15 |  |  |
Metastatic, no previous anthracyclines | Control | Epirubicin | 60 mg/m², d 1 | Every 3 weeks for 6 cycles | Trudeau ME, 1999 |
|  |  | Docetaxel | 75 mg/m², d 1 |  |  |
|  | Experimental | Epirubicin | 25 mg/m², dd 1-8-15 | Every 4 weeks for 6 cycles | Wenzel C, 2002 |
|  |  | Docetaxel | 30 mg/m², dd 1-8-15 |  |  |
Metastatic, previously treated with anthracyclines | Control | Capecitabine | 1000 mg/m², b.i.d., dd 1-14 | Every 3 weeks for 6 cycles | Pronk LC, 2000 |
|  |  | Docetaxel | 75 mg/m², d 1 |  |  |
|  | Experimental | Capecitabine | 625 mg/m², b.i.d., dd 5-18 | Every 4 weeks for 6 cycles | Nadella P, 2002 |
|  |  | Docetaxel | 35 mg/m², dd 1-8-15 |  |  |