The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

BMC Cancer

Table 2 Claudin-7 mRNA levels in normal and affected tissues normalised to the β-actin mRNA level.

Variable	mRNA level in normal tissue Mean ± S.D.	P^a	mRNA level in adenomas/carcinomas Mean ± S.D.	P^a	P^b
Healthy individuals	1.19 ± 0.70
Individuals with mild/moderate dysplasia	1.24 ± 0.67	NS	0.84 ± 0.58	NS	<0.001
Individuals with severe dysplasia	1.34 ± 0.75	NS	0.87 ± 0.69	NS	<0.01
Cancer patients	0.82 ± 0.73 (distant) 0.83 ± 0.66 (adjacent)	NS NS	0.44 ± 0.48 "	<0.001	<0.01 <0.001

NS = not significant.
a) p value for the comparison to the expression levels in tissue from healthy individuals using Kruskal Wallis and Dunn's Multiple Comparison test.
b) p value for the comparison of the expression levels in normal and affected tissue from the same individual using Paired Student's t-test.

ISSN: 1471-2407