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Figure 2 | BMC Cancer

Figure 2

From: Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation

Figure 2

The inhibitors 17-AAG, EC154, and LBH589 inhibit HIF-dependent gene transcription in CCRCC cells. The CCRCC cell line UMRC2 was treated for 16 h with inhibitors as in Figure 1. Total mRNA was isolated and HIF-α regulated genes analyzed by qRT-PCR. Values were normalized to GAPDH and are presented relative to control cells, with standard deviation shown. All drug treatments significantly reduced all transcript levels (*) as determined by ANOVA and Student's t-test (p < 0.05).

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BMC Cancer

ISSN: 1471-2407

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