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Table 3 Stages and Prior Systemic Therapies of DAB/IL2 Responders

From: Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

Stage

Age

Prior Systemic Therapy

# Cycles

Response

M1A (7/10)

59

None

4

PR

 

78

None

2

SD

 

83

None

2

MR

 

64

ADI, BCT, αCTLA4, VAC

4

PR

 

60

AIFN, BCT, TEM

4

PR

 

45

ADI, IFN, VAC

4

PR

 

75

AIFN, BCT

4

SD

M1B (1/8)

67

ADI

4

SD

M1C (14/42)

78

None

2

PR

 

83

None

3

PR

 

82

None

3

PR

 

61

None

4

PR

 

59

None

4

MR

 

47

BCT, HDIL2, TKI258

3

PR

 

62

αCTLA4

4

PR

 

55

BCT, HDIL2, TKI258

4

MR

 

70

ADI, BCT

2

MR

 

30

BCT

4

MR

 

30

BCT, HDIL2, αCTLA4, TKI258

2

MR

 

45

BCT

4

MR

 

61

BCT

3

MR

 

58

ADI, VAC

4

MR

  1. Abbreviations: ADI adjuvant dacarbazine/low-dose IL-2; BCT biochemotherapy; αCTLA4 anti-cytotoxic T lymphocyte Antigen 4 antibody; VAC peptide vaccines; TEM temozolomide; IFN interferon; AIFN adjuvant interferon; HDIL2 high-dose IL-2; TKI258 tyrosine kinase inhibitor 258