Figure 4

Tumor regression by α-TEA plus trastuzumab treatment. SCID mice (n = 9 to 10 mice per group) received a s.c. injection of MDA-MB-453 cells. After tumor establishment (day 15 post-tumor injection), mice received α-TEA in the diet (~2 mg/day/mouse) until day 63 (red bar) or 40 μg trastuzumab by i.p. injection, every 2 to 3 days for a total of 12 injections until day 40 (green bar). One mouse in the α-TEA + trastuzumab group died of unknown cause on day 35 post-tumor cell injection and was excluded from analysis. (A) Individual tumor volumes. (B) Tumor frequency.