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Table 3 Cumulative duration of statin use in cases and controls in 13 to 72 months prior to the index date by cancer site (in cases and matched controls with at least 6 years of medical records)

From: Exposure to statins and risk of common cancers: a series of nested case-control studies

 

Less than 12 months

13 to 24 months

25 to 48 months

49 months and more

 

cancer

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

P-* value

breast†

433/1811

1.01 (0.90 to 1.13)

289/1292

0.93 (0.81 to 1.07)

430/1685

1.07 (0.95 to 1.21)

329/1439

0.95 (0.83 to 1.09)

0.719

prostate

668/2784

1.05 (0.95 to 1.15)

560/2187

1.14 (1.03 to 1.26)

796/3295

1.09 (0.99 to 1.19)

750/3242

1.05 (0.95 to 1.16)

0.084

colorectal‡

525/2038

1.05 (0.95 to 1.17)

400/1595

1.04 (0.92 to 1.17)

539/2230

1.02 (0.92 to 1.14)

536/1907

1.23 (1.10 to 1.38)

0.002

lung

485/1857

1.02 (0.90 to 1.15)

406/1478

1.11 (0.97 to 1.27)

549/2233

1.01 (0.90 to 1.14)

558/2053

1.18 (1.05 to 1.34)

0.013

blood

255/1082

0.84 (0.72 to 0.98)

201/860

0.81 (0.68 to 0.96)

277/1307

0.73 (0.63 to 0.84)

240/1090

0.76 (0.65 to 0.89)

< 0.001

bladder

209/785

1.13 (0.95 to 1.34)

174/611

1.18 (0.98 to 1.42)

240/952

1.06 (0.90 to 1.25)

233/777

1.29 (1.08 to 1.54)

0.014

skin

120/422

1.19 (0.95 to 1.49)

61/347

0.74 (0.55 to 0.99)

141/474

1.23 (0.99 to 1.54)

111/432

1.08 (0.84 to 1.39)

0.373

oesophagus

126/571

0.82 (0.67 to 1.02)

97/394

0.91 (0.71 to 1.17)

128/601

0.82 (0.66 to 1.02)

145/540

1.04 (0.83 to 1.30)

0.705

pancreas

87/367

0.85 (0.66 to 1.10)

73/269

1.02 (0.76 to 1.36)

113/390

1.09 (0.86 to 1.40)

92/371

0.97 (0.74 to 1.28)

0.521

stomach

76/317

0.87 (0.66 to 1.15)

69/271

0.90 (0.67 to 1.20)

94/404

0.86 (0.67 to 1.11)

83/371

0.85 (0.64 to 1.12)

0.167

All cancers

3467/13935

1.01 (0.97 to 1.05)

2752/10855

1.02 (0.98 to 1.07)

3868/15708

1.00 (0.96 to 1.04)

3534/14108

1.04 (1.00 to 1.09)

0.057

  1. # Adjusted for Townsend quintile, body mass index, smoking status, myocardial infarction, coronary heart disease, diabetes, hypertension, stroke, rheumatoid arthritis, use of NSAIDs, Cox2-inhibitors, aspirin
  2. † Also adjusted for family history of breast cancer, benign breast disease, use of oral contraceptives, hormone-replace therapy
  3. ‡ Also adjusted for colitis and Crohn's disease
  4. * Trend test based on number of months prescribed
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BMC Cancer

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