Figure 5

Increased levels of circulating IGF-I have no effect on tumor type or mammary gland signaling. A.) Representative H&E staining of mammary tumors promoted by MMTV-ErbB2 (top) or TTR-IGF-I-ErbB2 bigenic (bigenic-bottom). Both groups had similar tumor phenotypes which were predominantly adenocarcinomas. B.) Representative immunoblot of phosphorylated (p) and total (T) AKT and Erk ½ signaling in normal mammary glands (M) and tumors (T). *** = p < 0.001; Magnification: 40 ×. C = representative wild type females; I = representative TTR-IGF-I transgenic females