Figure 5
From: Repression of human activation induced cytidine deaminase by miR-93 and miR-155
Model of miR-93 and miR-155 regulation of AID mediated genomic instability. In normal cells, top, genome stability is maintained by inhibition of AID translation by miR-93 and/or miR-155 when AID mRNA levels are low. Bottom, in antigen activated B cells or when misregulated, levels of AID mRNA exceed the capacity for miR translational repression. AID translation results in AID protein levels that support Ig gene diversification, mutagenesis and genome instability.