Table 3 Clinicopathologic and molecular characteristics of colorectal cancers in patients with stage II or stage III colorectal cancers who underwent surgery alone or received fluoropyrimidine-based adjuvant chemotherapy
| Â | CIMP-low/negative Surgery alone (n = 39) | CIMP-low/negative Surgery + CRx (n = 61) | CIMP-high Surgery alone (n = 7) | CIMP-high Surgery + CRx (n = 17) |
|---|---|---|---|---|
Age (yrs) | Â | Â | Â | Â |
   Mean ± SD | 63.4 ± 11.0 | 58.7 ± 10.8 | 72.9 ± 7.1 | 60.1 ± 10.7 |
   Median (Range) | 66.0 (42 - 83) | 64.0 (36 - 75) | 75.0 (63 - 82) | 63.0 (33 - 72) |
Gender (%) | Â | Â | Â | Â |
   Male | 23 (59.0) | 34 (55.7) | 3 (42.9) | 11 (64.7) |
   Female | 16 (41.0) | 27 (44.3) | 4 (57.1) | 6 (35.3) |
Tumor site (%) | Â | Â | Â | Â |
   Proximal | 14 (35.9) | 19 (31.1) | 6 (85.7) | 12 (70.6) |
   Distal | 25 (64.1) | 42 (68.9) | 1 (14.3) | 5 (29.4) |
Lymph node metastasis (%) | Â | Â | Â | |
   Absent | 37 (94.9) | 25 (41.0) | 6 (85.7) | 10 (58.8) |
   Present | 2 (5.1) | 36 (59.0) | 1 (14.3) | 7 (41.2) |
AJCC stage (%) | Â | Â | Â | Â |
   II | 37 (94.9) | 25 (41.0) | 6 (85.7) | 10 (58.8) |
   III | 2 (5.1) | 36 (59.0) | 1 (14.3) | 7 (41.2) |
Differentiation (%) | Â | Â | Â | Â |
   Well/Moderate | 34 (87.2) | 56 (91.8) | 6 (85.7) | 9 (52.9) |
   Poor/Mucinous | 5 (12.8) | 5 (8.2) | 1 (14.3) | 8 (47.1) |
Mucinous histology (%) | Â | Â | Â | Â |
   Absent | 36 (92.3) | 59 (96.7) | 7 (100.0) | 12 (70.6) |
   Present | 3 (7.7) | 2 (3.3) | 0 (0.0) | 5 (29.4) |
BRAF (%) | Â | Â | Â | Â |
   Wild type | 39 (100.0) | 61 (100.0) | 4 (57.1) | 14 (82.4) |
   Mutation | 0 (0.0) | 0 (0.0) | 3 (42.9) | 3 (17.6) |
KRAS (%) | Â | Â | Â | Â |
   Wild type | 22 (56.4) | 45 (73.8) | 3 (42.9) | 11 (64.7) |
   Mutation | 17 (43.6) | 16 (26.2) | 4 (57.1) | 6 (35.3) |
MGMT methylation (%) | Â | Â | Â | Â |
   Absent | 26 (66.7) | 47 (77.0) | 3 (42.9) | 5 (29.4) |
   Present | 13 (33.3) | 14 (23.0) | 4 (57.1) | 12 (70.6) |
MSI status (%) | Â | Â | Â | Â |
   MSS/MSI-low | 33 (84.6) | 50 (82.0) | 4 (57.1) | 3 (17.6) |
   MSI-high | 6 (15.4) | 11 (18.0) | 3 (42.9) | 14 (82.4) |