Figure 3

The TB interface gene signature resembles human bone metastases and osteoclastogenesis. A. The NTP algorithm was used to predict whether human breast cancer metastases (lung, bone and brain) significantly (FDR < 0.2) resemble the TB interface of our mouse osteoclastic model. B. SubMap based de novo analysis was used to compare the TB interface and TA area gene expression profiles to human breast cancer metastases samples. p-values are color coded in the bar. C. The NTP algorithm was used to predict whether the gene expression profile of the TB interface resembles osteoclasts (72 h RANKL treatment; blue) or OCPs (0 and 24 h RANKL treatment; yellow and red, respectively). Samples predicted with FDR p > 0.2 do not resemble either the TA area or the TB interface. Samples and prediction significance are shown in the colored bar on the top of the hierarchical cluster.