Figure 4

Area of proliferating tumour 21 days after tumour inoculation in irbesartan sensitive (IRB-sensitive; AT1R ^LOW ) and insensitive (IRB-insensitive; AT1R ^HI ) tumours either treated with irbesartan (IRB) or untreated. (A). The percent of Ki67 positive (proliferating) cells per tumour area (measured at 400x magnification) (B). The number of Ki67 positive cells in the liver surrounding tumour (measured at 400x magnification) (C). n = 5 or 6 for each group except for AT1R^LOW tumours which, because of the reduced tumour load, had additional samples (n of 10). Between 10 and 30 images were taken from each mouse across 1 to 5 tumours (dependent on tumour load). Representative images for each graph are shown to the right. Significant P values between 0.01 and 0.05 are shown with an * and solid line, those less than 0.01 are shown with **, while those of interest with P values between 0.1 and 0.05 are indicated with a dotted line and no *, but with P value shown. Data are presented as mean ± S.E.M.