Figure 3From: Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation Intensity of AT1R staining 21 days after tumour inoculation in untreated (control) animals with tumours showing sensitivity to irbesartan or insensitive to irbesartan treatment. Tumours were grouped into small (≤ 250 μm), medium (250 μm to 1000 μm), or large (≥ 1000 μm) in diameter. Representative images are shown below. n = 5 or 6 for each group except for AT1RLOW tumours which, because of the reduced tumour load, had additional samples (n of 10). The entire tumour was imaged for analysis. Significant P values between 0.01 and 0.05 are shown with an *, those less than 0.01 are shown with **. Data are presented as mean ± S.E.M.Back to article page