Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

Table 4 Stratification analysis for associations between PLCE1 variant genotypes and risk of SCCHN arising at non-oropharyngeal sites

Variables	rs2274223 (cases/controls)		Adjusted OR^a(95%CI)	rs11599672 (cases/controls)		Adjusted OR^a(95%CI)	Combined effect of risk alleles ^b(cases/controls)		Adjusted OR^a(95%CI)
	AA	AG/GG		TT	TG/GG		0-1	2-6
Age, yr
≤57(median)	96/286	133/285	1.44 (1.02-2.02)	133/284	97/279	0.71 (0.50-1.00)	39/140	189/417	1.68 (1.09-2.59)
>57(median)	128/218	181/300	1.19 (0.87-1.63)	151/235	156/276	0.88 (0.64-1.20)	72/123	234/387	1.18 (0.82-1.70)
Gender
Females	84/119	100/139	0.97 (0.64-1.47)	96/110	89/145	0.73 (0.48-1.10)	44/74	140/177	1.30 (0.81-2.08)
Males	140/385	214/446	1.51 (1.14-2.00)	188/409	164/410	0.84 (0.64-1.10)	67/189	283/627	1.41 (1.00-1.98)
Smoking status
Never	46/236	57/298	0.99 (0.65-1.53)	54/266	48/261	0.85 (0.55-1.31)	27/116	74/407	0.81 (0.50-1.33)
Ever	178/268	257/287	1.33 (1.02-1.72)	230/253	205/294	0.73 (0.56-0.94)	84/147	349/397	1.65 (1.21-2.26)
Alcohol status
Never	79/210	76/262	0.84 (0.57-1.23)	86/223	69/244	0.67 (0.46-0.99)	34/112	120/352	1.33 (0.83-2.11)
Ever	145/294	238/323	1.69 (1.25-2.28)	198/296	184/311	0.86 (0.64-1.15)	77/151	303/452	1.42 (1.00-2.03)
Stage
I-II	87/504	137/585	1.40 (1.03-1.91)	114/519	111/555	0.84(0.62-1.14)	44/263	178/804	1.46 (1.01-2.13)
III-IV	137/504	177/585	1.24 (0.94-1.65)	170/519	142/555	0.78(0.59-1.03)	67/263	245/804	1.32 (0.94-1.85)

^a Adjusted for age, sex, smoking and alcohol status (the stratified factor in each stratum excluded).
^b The risk alleles: rs2274223G, rs3203713G and rs11599672T.

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