Figure 3
From: SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
SIP1 protein expression in human liver tissues. Photographs are representative of SIP1 immunohistochemistry in human liver tissues. (A) Normal tissue shows strong, diffuse cytoplasmic staining. (B) Heterogenous expression of SIP1 in HCC. Tumor section displays faint immunostaining, except for a few cells with strong immunoreactivity. (C) A tissue array sample includes both tumor and non-tumor cells that differentially express SIP1. (D) Adenocarcinoma metastasis to liver. While metastatic cells are negatively stained, hepatocytes strongly express SIP1. N: Normal hepatocytes; T: HCC cells; MT: Metastatic adenocarcinoma cells (Scale Bars: 50 μm).