Figure 5

Quantification of cultured cells displaying aberrant morphology after knockdown of MPM prognostic genes. The Condensed Chromatin Index (A) and Cell Number Index (B) were calculated as described in the Methods in tumor cell transfected with 3 different siRNA molecules per gene (as represented by individual bars) targeting MPM prognostic genes ("ARHGDIA", "COBLL1", "TM4SF1"), positive control genes ("KIF11", "PLK1"), or non-specific siRNAs as negative controls ("Neg"). Error bars, SEM. *, statistically significant (P < 0.05) relative to negative control.