Figure 3
The associations between the inflammatory chemokines CCL2 & CCL5 and the inflammatory cytokines TNFα & IL-1β, in breast cancer patients. The analyzed factors were sub-divided to two groups: Group 1 - The inflammatory cytokines TNFα & IL-1β; Group 2 - The inflammatory chemokines CCL2 & CCL5; Detailed explanation of graphs a, b and c is provided further below. (a) In DCIS patients, p = 0.002 for associations between Group 1 and Group 2. (b) In IDC-no-relapse patients, p = 0.036 for associations between Group 1 and Group 2. (c) In IDC-with-relapse patients, p = 0.627 for associations between Group 1 and Group 2. Explanation: In each group of breast cancer patients (DCIS, IDC-no-relapse, IDC-with-relapse), the graphs show the following: (1) CCL2: The graph shows the incidence of CCL2 expression when it was co-expressed with TNFα and IL-1β in the same biopsy [presented in the graph as "CCL2 (+ TNFα) (+ IL-1β)"], as compared to the incidence of CCL2 expression when it was NOT co-expressed with TNFα and IL-1β in the same biopsy [presented in the graph as "CCL2 (- TNFα) (- IL-1β)"]; (2) CCL5: The graph shows the incidence of CCL5 expression when it was co-expressed with TNFα and IL-1β in the same biopsy [presented in the graph as "CCL5 (+ TNFα) (+ IL-1β)"], as compared to the incidence of CCL5 expression when it was NOT co-expressed with TNFα and IL-1β in the same biopsy [presented in the graph as "CCL5 (- TNFα) (- IL-1β)"]; (3) TNFα: The graph shows the incidence of TNFα expression when it was co-expressed with CCL2 and CCL5 in the same biopsy [presented in the graph as "TNFα (+ CCL2) (+ CCL5)"], as compared to the incidence of TNFα expression when it was NOT co-expressed with CCL2 and CCL5 in the same biopsy [presented in the graph as "TNFα (- CCL2) (- CCL5)"]; (4) IL-1β: The graph shows the incidence of IL-1β expression when it was co-expressed with CCL2 and CCL5 in the same biopsy [presented in the graph as "IL-1β (+ CCL2) (+ CCL5)"], as compared to the incidence of IL-1β expression when it was NOT co-expressed with CCL2 and CCL5 in the same biopsy [presented in the graph as "IL-1β (- CCL2) (- CCL5)"];