Table 1 Patient characteristics (n = 221)
From: Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
| Â | Â | (%) |
|---|---|---|
Age (years) | Â | Â |
Median | 47 | Â |
Mean | 49 | Â |
Range | 23 - 85 | Â |
Histological subtype (n = 221) | Â | Â |
Squamous cell carcinoma | 161 | (72.9) |
Adenocarcinoma | 35 | (15.8) |
Adenosquamous cell carcinoma | 25 | (11.3) |
Tumor stage (FIGO) (n = 221) | Â | Â |
Ia1 | 0 | (0.0) |
Ia2 | 3 | (1.4) |
Ib1 | 113 | (51.1) |
Ib2 | 20 | (9.0) |
IIa | 17 | (7.7) |
IIb | 44 | (19.9) |
IIIa | 0 | (0.0) |
IIIb | 1 | (0.5) |
IVa | 7 | (3.2) |
IVb | 16 | (7.2) |
Lymph node involvement (n = 221) | Â | Â |
N0 | 168 | (76.0) |
N1 | 53 | (24.0) |
Removed lymph nodes (n = 221) | Â | Â |
Median | 27 | Â |
Mean | 30 | Â |
Range | 2 - 88 | Â |
Affected lymph nodes (n = 53) | Â | Â |
Median | 2 | Â |
Mean | 3 | Â |
Range | 1 - 14 | Â |
Distant metastasis (n = 181) | Â | Â |
M0 | 165 | (91.2) |
M1 | 16 | (8.8) |
Tumor grade (n = 215) | Â | Â |
G1 | 9 | (4.2) |
G2 | 95 | (44.2) |
G3 | 111 | (51.6) |
Lymphovascular space invasion (n = 196) | Â | Â |
L0 | 64 | (32.7) |
L1 | 132 | (67.3) |
Vascular invasion (n = 169) | Â | Â |
V0 | 151 | (89.3) |
V1 | 18 | (10.7) |
Surgical therapy (n = 181) | Â | Â |
Radical hysterectomy | 180 | (99.5) |
Trachelectomy | 1 | (0.5) |
Preoperative SCC serum concentration (μg/l) (n = 144) |  |  |
Median value | 1.4 | Â |
Mean | 5.2 | Â |
Range | 0.2 - 107.0 | Â |
Adjuvant Therapy (n = 180) | Â | Â |
No therapy | 88 | (48.9) |
Adjuvant radiotherapy | 44 | (24.4) |
Adjuvant concomitant chemoradiotherapy | 48 | (26,7) |
Follow-up (months) (n = 175) | Â | Â |
Median | 49 | Â |
Mean | 63 | Â |
Range | 2-193 | Â |
Disease free surviving | 131 | (74.9) |
Disease recurrence | 44 | (25.1) |
Died of disease | 38 | (21.7) |
CAIX expression (IRS) (n = 221) | Â | Â |
Median expression | 2 | Â |
Mean | 3 | Â |
Range | 0 - 12 | Â |
IRS 0 | 40 | 18.1 |
IRS 1 | 44 | 19.9 |
IRS 2 | 35 | 15.8 |
IRS 3 | 9 | 4.1 |
IRS 4 | 32 | 14.5 |
IRS 6 | 29 | 13.1 |
IRS 8 | 2 | 0.9 |
IRS 9 | 23 | 10.4 |
IRS 12 | 7 | 3.2 |
CAIX serum concentration (pg/mL) (n = 46) | Â | Â |
Median concentration | 104 | Â |
Mean | 137 | Â |
Range | 23-499 | Â |