Characteristic | Locoregional recurrences | Contralateral breast cancer | Distant metastases | 2nd primary cancer other than breast | Breast cancer death | |||||
---|---|---|---|---|---|---|---|---|---|---|
RR (95% CI) | p | RR (95% CI) | P | RR (95% CI) | P | RR (95% CI) | p | RR (95% CI) | p | |
Histological size of the tumor (for 1 mm increase) | 1.02 (0.99-1.06) | 0.17 | 1.02 (0.97-1.06) | 0.54 | 1.02 (1.00-1.05) | 0.08 | 1.01 (0.93-1.10) | 0.75 | 1.02 (0.99-1.05) | 0.27 |
Extensive intraductal component (EIC) | ||||||||||
- No (ref) | 1 | 1 | 1 | -- | 1 | |||||
- Yes | 3.34 (0.89-12.5) | 0.07 | 0.99 (0.13-7.46) | 1.00 | 1.55 (0.34-7.06) | 0.57 | -- | -- | 1.43 (0.20-10.8) | 0.73 |
Grade | ||||||||||
- Grade1(ref) | 1 | 1 | 1 | 1 | 1 | |||||
- Grade 2 | 1.84 (1.11-3.07) | 0.02 | 1.45 (0.78-2.70) | 0.24 | 2.68 (1.58-4.53) | < 0.001 | 0.68 (0.23-2.01) | 0.48 | 3.64 (1.74-7.60) | < 0.001 |
- Grade 3 | 2.12 (1.17-3.84) | 0.01 | 0.94 (0.40-2.21) | 0.88 | 3.39 (1.91-6.02) | < 0.001 | 1.32 (0.37-4.75) | 0.67 | 5.54 (2.58-11.9) | < 0.001 |
# positive nodes | ||||||||||
- 0 (ref) | 1 | 1 | 1 | -- | 1 | |||||
- 1-3 | 2.60 (1.30-5.19) | 0.007 | 1.17 (0.34-3.97) | 0.81 | 2.41 (1.29-4.47) | 0.006 | -- | -- | 2.92 (1.50-5.68) | 0.002 |
- ≥4 | 4.40 (1.80-10.7) | 0.001 | 0.66 (0.13-3.45) | 0.62 | 6.91 (3.41-14.0) | < 0.001 | -- | -- | 8.03 (3.71-17.4) | < 0.001 |
Lympho-vascular invasion | ||||||||||
- No (ref) | 1 | 1 | 1 | 1 | 1 | |||||
- Yes | 1.29 (0.84-1.98) | 0.24 | 0.41 (0.19-0.90) | 0.03 | 1.47 (1.04-2.08) | 0.03 | 1.40 (0.51-3.83) | 0.51 | 1.27 (0.87-1.91) | 0.26 |
Surgical excision margin status | ||||||||||
- Clear (ref) | 1 | 1 | 1 | 1 | 1 | |||||
- Invasion | 0.95 (0.64-1.43) | 0.81 | 2.36 (1.40-3.98) | 0.001 | 1.05 (0.74-1.48) | 0.78 | 0.57 (0.19-1.73) | 0.32 | 1.12 (0.75-1.67) | 0.59 |
Progesterone receptor status | ||||||||||
-Positive(ref) | 1 | 1 | 1 | 1 | 1 | |||||
- Negative | 1.26 (0.84-1.88) | 0.26 | 1.21 (0.70-2.09) | 0.49 | 1.32 (0.93-1.86) | 0.12 | 0.33 (0.11-1.03) | 0.06 | 1.90 (1.26-2.87) | 0.002 |
Treatment combination | ||||||||||
- Radiotherapy (ref) | 1 | 1 | 1 | -- | 1 | |||||
- Radio- and chemotherapy | 0.23 (0.11-0.50) | < 0.001 | 1.22 (0.33-4.55) | 0.77 | 0.52 (0.27-1.02) | 0.06 | -- | -- | 0.56 (0.27-1.16) | 0.12 |
- Radio- and hormonal therapy | 0.35 (0.16-0.77) | 0.009 | 0.78 (0.21-2.91) | 0.71 | 0.59 (0.30-1.13) | 0.11 | -- | -- | 0.48 (0.24-0.99) | 0.05 |
- Radio- and chemo- and hormonal therapy | 0.06 (0.01-0.49) | 0.008 | 0.74 (0.07-7.60) | 0.80 | 0.33 (0.11-0.99) | 0.05 | -- | -- | 0.28 (0.07-1.06) | 0.06 |