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Table 2 Sensitivity of cell lines as measured in a clonogenic survival assay.

From: Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

 

APO866

CHS-828

TP201565

NYH

1.5 ± 0.5

1.7 ± 1.2

0.02 ± 0.01

HCT-116

10.9 ± 6.1

12.2 ± 7.4

0.4 ± 0.3

PC-3

3.8 ± 3.1

8.8 ± 8.4

0.3 ± 0.3

  1. LD50 values (measured in nM) of the parental cell lines NYH, HCT-116 and PC-3 when treated with APO866, CHS-828 or TP201565. LD50 values are represented with standard deviations.
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BMC Cancer

ISSN: 1471-2407

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