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Figure 2 | BMC Cancer

Figure 2

From: Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Figure 2

NAMPT expression in tumor cell lines and transfected HEK293T cells. A: Protein expression of NAMPT in parental and resistant cell lines. 1-7: NYH, NYH/CHS, HCT-116, HCT-116/APO866, HCT-116/TP201565, PC-3 and PC-3/TP201565. B: Comparison of protein expression of NAMPT in 1 PC-3, 2 PC-3/TP201565, 3 HEK293T cells transfected with control vector and 4 HEK293T cells transfected with an expression vector containing the NAMPT gene. The expression is representative for transfections with wild type and mutant NAMPT. GAPDH is used as loading control. C: IC50 values of APO866 in HEK293T cells, untransfected and transfected with control vector, wild type NAMPT and NAMPT containing H191R, D93del or Q388R/K342R. Values are shown in nM ± SD.

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BMC Cancer

ISSN: 1471-2407

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