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Table 2 Overlapping gains and losses that differentiate BLBCs and BRCA1-mutated tumors from luminal breast tumors

From: BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

a

Chr - region

Start (Mb)

End (Mb)

peaks (Mb) BRCA1-related

peaks (Mb) BLBC

Gains

1p

58.05

65.50

62.00

61.20

 

2p-1

23.35

25.95

26.45

27.45

 

2p-2

56.80

65.20

60.85

63.95

 

3q-1

151.00

161.10

150.85

154.85

 

3q-2

175.80

186.40

178.55

179.80

 

6p-1

4.30

29.75

10.90, 19.20

14.05

 

6p-2

37.05

58.65

42.60, 53.85

36.65

 

6q-1

90.35

90.75

86.50

91.00

 

6q-2

105.20

112.30

107.15

107.75

 

6q-3

115.00

120.40

no peak in region

 
 

6q-4

123.55

138.75

125.55

135.60

 

7q-1

132.80

139.40

134.40

130.25

 

7q-2

155.15

157.65

156.95

157.65

 

8q

127.40

132.95

120.95

121.95, 135.3

 

10p-1

1.30

12.45

5.10

6.45

 

10p-2

25.65

30.70

24.90

29.20

 

12p

0.25

11.60

0.25, 16.10

0.25

 

13q

101.25

107.00

99.55

110.35

 

19q

36.50

41.75

39.15

41.10

Losses

3p

53.00

53.25

53.85

62.55

 

4p

15.65

27.05

18.55

11.00, 26.65

 

5q-1

50.05

146.95

57.70, 70.75, 89.75,102.30, 116.25, 133.80

70.05, 89.85, 108.60,118.55, 136.30

 

5q-2

161.40

171.20

161.05, 178.30

157.30

 

10q-1

80.65

95.50

83.30, 90.15

91.05

 

10q-2

105.55

111.35

109.70

108.60

 

12q-1

47.70

48.35

no peak in region

42.15

 

12q-2

54.30

59.25

55.25

58.40

 

14q-1

38.30

44.75

40.65

36.35

 

14q-2

48.35

92.95

57.35, 79.90, 98.00

55.20, 66.15, 81.0, 95.05

 

15q

35.10

49.65

44.40

33.70, 42.85

b

Chr - region

Start (Mb)

End (Mb)

peaks (Mb)

 

Gains

1q

176.70

215.40

177.35, 202.75

 
 

8p

35.95

38.90

41.5

 
 

16p

4.30

27.75

15.8

 

Losses

6q-1

79.05

87.25

82.35

 
 

6q-2

142.75

149.25

no peak in region

 
 

6q-3

156.90

157.85

160.05

 
 

11q

104.45

125.35

112.30, 126.60

 
 

13q

91.70

95.50

99.1

 
 

16q

45.15

88.50

52.30, 79.40

 
  1. Table 2: a. Overlapping differential CNAs of BLBCs and BRCA1-mutated breast tumors vs luminal breast tumors. b. Overlapping differential CNAs of luminal breast tumors vs BRCA1-mutated breast tumors and BLBCs.
  2. Differential gains and losses determined by comparative-KC-SMART (Figure 1b-c). a) Overlapping regions that differentiate BRCA1-mutated tumors and BLBCs from luminal tumors. b) overlapping regions that differentiate luminal-J and luminal-H tumors from BLBC/BRCA1-mutated tumors. KSE peak locations are listed for all tumor groups; peaks in italics fall just outside the region of overlap.