Skip to main content
Figure 5 | BMC Cancer

Figure 5

From: Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Figure 5

Induction of hyperacetylated histone H3 (AcH3) and H4 (AcH4) during the treatment with oridonin. SW1116 cells were treated with 25 μM oridonin for 72 hours. (A) Heterochromatin formation was shown by DAPI staining. Distribution of AcH3 and AcH4 were examined by immunofluorescence staining with the indicated antibodies (×200). (B) Protein levels of AcH3 and AcH4 were detected by Western blots with the indicated antibodies. H3 , H4 and GAPDH were used as loading control. (C) The graph shows densitometric analysis of the expression of AcH3 and AcH4 relative to GAPDH. Symbol * represents P < 0.05 compared with control group.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us