Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Table 3 Workflow time table

Approval of ethics committee
↓
Diagnosis of chordoma of the skull base and completion of pre-radiation treatment examinations (biopsy, operation, staging)
↓
Informed consent of the patient and patient registration by the study office at HIT
↓
Stratification and Randomisation
↓
Arm A: carbon ion RT (63 Gy E ± 5%, fractionation 4-6 × 3.0 Gy E) Arm B: proton RT (72 Gy E ± 5%, fractionation 4-6 × 2.0 Gy E)
↓
Treatment planning for particle therapy
↓
Particle therapy
↓
Follow-up

ISSN: 1471-2407