Figure 4

Up or down - regulation of DEFA 6 expression in 17 individuals*. *One of the donors had two adenomas, therefore the figure show 18 samples. The patients are characterized for their age, gender and grade of cancer. N.D. means that the stage was not determined. The scale of the y axis is logarithmic. None of the patients has simultaneously down-regulated DEFA 6 in both, adenoma as well as fully blown cancer. The dotted horizontal line at 1 indicates that DEFA 6 expression would be un-effected. For the first patient on the left, no comparison of adenoma with carcinoma was possible, since the donor had developed only adenoma. From the 17 other samples, 13 revealed a higher expression in adenoma than in carcinoma, 1 case (encircled) showed essentially no change and 3 objects (in rectangular boxes) had the highest expression in carcinoma.