Table 2 TGFBR2, BAX, IGF2R, MSH3, MSH6 microsatellite sequences, BRAF and KRAS mutation frequency and MLH1 promoter hypermethylation status in the MSI-H colorectal cancer according to the large bowel of origin (rectal/sigmoid carcinomas compared with those located elsewhere in the colon from both series)
Tumor location | TGFBR2 (%) | BAX (%) | IGF2R (%) | MSH3 (%) | MSH6 (%) | MLH1methylation (%) | KRAS (%) | BRAF (%) |
|---|---|---|---|---|---|---|---|---|
Proximal Colon | 23/26 (88) | 12/26 (46) | 8/26 (31) | 20/26 (77) | 5/26 (19) | 10/19 (53) | 5/26 (19) | 9/21 (43) |
Rectum/Sigmoid | 4/16 (25) | 3/16 (19) | 3/16 (19) | 0/16 (0) | 1/16 (6) | 0/12 (0) | 4/16 (25) | 2/12 (17) |
P = 0.00005 | P = 0.102 | P = 0.485 | P = 0.0000005 | P = 0.380 | P = 0.004 | P = 0.711 | P = 0.249 |