Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data

Table 3 Performances of ER status classifiers

Classifier	Selected Genes	Patient Prediction Error
SNSS/SNSS	1 gene total: ESR1	0.1017
Lasso/KNN	1 gene total: ESR1	0.1186
Lasso/RF	1 gene total: ESR1	0.1186
SNSS/RF	2 genes total: ESR1, TOM1L1	0.1186
SNSS/KNN	2 genes total: ESR1, TOM1L1	0.161
Lasso/Lasso	19 genes total: ESR1, TOM1L1, CPT1A, SRPR, APOD, COIL, CYB561, C10orf116, ST6GALNAC2, MICALL1, ABAT, FBP1, CA12, JAG1, PDCD4, FXYD5, RSAD1, C14orf132, MRPL35	0.1864
RDA/RDA	7 genes total: ESR1, EIF3D, CPT1A, COIL, INPP4B, SIAH2, RSAD1	0.4661
RDA/RF	No genes selected	0.5254
RDA/KNN	1 gene total: CPT1A	0.5254

Summaries of the performances of the nine ER status classifiers, including the selected genes and the patient ER status prediction error.

ISSN: 1471-2407