Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis

Table 2 Univariate analysis of survival.

	At 6 months	At 12 months
	(%)	(%)	P
Tumor type
Malignant melanoma	32	8
Renal cell carcinoma	38	30
Colorectal cancer	26	18	0.08
WBI schedule
5 × 4 Gy	23	8
10 × 3 Gy	24	14
15 × 3/20 × 2 Gy	51	37	<0.001
Age
≤62 years	38	22
≥63 years	26	17	0.10
Gender
Female	26	24
Male	35	18	0.52
Karnofsky Performance Score
<70	7	2
≥70	49	32	<0.001
Number of metastases
1-3	54	38
≥4	17	6	<0.001
Extracerebral metastases
No	57	32
Yes	20	13	<0.001
Interval from first diagnosis to WBI
≤24 months	31	16
≥25 months	33	21	0.30
RPA class
1	96	61
2	37	25
3	8	2	<0.001

ISSN: 1471-2407