Figure 3

Association of NORE1 alteration with tumor progression. Correlation of NORE1 reduction with tumor stage and grade (A). Expression levels of NORE1A and NORE1B were compared between stages I, II, and III tumors, and between well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD) tumors. No association of NORE1A and NORE1B expression with K-Ras mutation in primary colorectal tumors (B). The mutational status of K-Ras in 80 primary carcinoma tissues was determined by SSCP and DNA sequencing analysis.