Figure 7From: Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis A hypothetical model proposed to explain RASSF1C action in breast cancer cells: we hypothesize that RASSF1C activates the Ras-Raf-ERK1/2 pathway leading to up-regulation of the CXCR4. Breast cancer cells expressing high number of CXCR4 receptor are attracted to migrate to secondary tissue sites where a cognate ligand (CXCL12) is expressed at higher levels (e.g., bone, liver, and lung).Back to article page