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Figure 1 | BMC Cancer

Figure 1

From: The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

Figure 1

Treatment with Sorafenib inhibits cell proliferation and induces apoptosis. SEM, RS4;11 and Jurkat cells were exposed to the indicated concentrations of Sorafenib. The proliferation of SEM, RS4;11 and Jurkat are significantly inhibited, with most pronounced effects at 96 h. Apoptotic and necrotic cells were analyzed using Annexin V/PI staining followed by flow cytometry. Apoptosis and necrosis rates increased in B- and T-ALL cell lines following Sorafenib treatment. Results are displayed as mean +/- SD of three independent experiments.

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BMC Cancer

ISSN: 1471-2407

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