Genotype | Body wt: (g) Placebo | Body wt. (g) 9cRA | DLP-(mg) Placebo | DLP-(mg) 9cRA |
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p27+/+ | 8 | 30.8 ± 4.3* | 10 | 27.2 ± 5.4* | 48.3 ± 13.1** | 45.6 ± 7.7** |
p27+/- | 10 | 35.8 ± 5.1 | 12 | 31.3 ± 5.6 | 67.2 ± 14.5 | 60.2 ± 10.5 |
p27-/- | 12 | 41.4 ± 5.6* | 10 | 35.5 ± 6.4* | 97.6 ± 21.0** x | 80.5 ± 18.6** x |
- These are the final measurements of body weight (g) at the end of experiment when the animals were sacrificed. DLP was isolated at autopsy, measured on an analytical balance and then frozen or embedded in 10% neutral formalin. Body and DLP weights were higher in p27-/- as compared to p27+/+ mice; *, p < 0.01; **, 0.001. 9cRA also decreased DLP weight in p27-/- mice (x) as compared to placebo-treated mice (p < 0.02).