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Table 2 Immunostaining of HAS1, HAS2 and HAS3 in human endometrium and its lesions

From: Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

  

HAS1

staining

intensity*

  

HAS2

staining

intensity*

  

HAS3

staining

intensity*

  
  

Epithelium

 

Stroma

Epithelium

 

Stroma

Epithelium

 

Stroma

 
  

n.d.

weak

moderate

n.d.

weak

n.d.

weak

moderate

n.d.

weak

n.d.

weak

moderate

n.d.

weak

Normal n = 10

 

4

2 (10-25%)

4 (10-50%)

7

3 (5-50%)

7

3 (5-10%)

0

8

2 (25%)

5

5 (10-20%)

0

9

1(10%)

Proliferating pm n = 5

5

0

0

5

0

5

0

0

1

4 (5%)

5

0

0

5

0

Hyperplasia # n = 4

1

3 (5-25%)

0

3

1 (10%)

1

2 (10-25%)

1 (50%)

3

1 (10%)

2

2 (10%)

0

3

1(25%)

Grade 1 n = 8

0

5 (5-50%)

3 (25-50%)

6

2 (5%)

2

5 (5-25)

1 (50%)

8

0

3

3 (5-25%)

2 (25-50%)

8

0

Grade 2 + 3 n = 8

0

2 (25-50%)

6 (5-50%)

8

0

0

5 (5-50%)

3 (5-50)

7

1 (5%)

0

3 (10-20%)

5 (10-25%)

8

0

  1. * num. of samples with % of positive cells (% in median; range when necessary)
  2. n.d. = not detected/negative
  3. # complex atypical hyperplasia
  4. pm = post-menopausal
  5. ‡ endometrioid endometrial adenocarcinoma