Figure 4From: PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer The paracrine action of ADAMTS1 on FPS cell invasion. (A) FPS cells were treated with V CM, P CM or P CM incubated with IgG or ADAMTS1 antibody for immunoneutralisation. Cell invasion through a monolayer of extracellular matrix was assessed after 24 hrs using a Boyden chamber assay. * represents statistical significance; P < 0.05. (B) FPS cells were treated with control (serum-free medium; SF) or SF medium with the addition of 1 or 10nM recombinant ADAMTS1 and cell invasion through a monolayer of extracellular matrix was assessed. * represents statistical significance of treated group relative to control; P < 0.05. Data are represented as mean ± SEM from at least 3 independent experiments.Back to article page