Table 5 Interaction between the studied polymorphisms and smoking status.
From: Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes
Smoking | IRRA95% CI | p-valueB | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Never | Past | Current | Smoking | ||||||||||
NC | NS | NC | NS | NC | NS | Never | Past | Current | |||||
NFkB -94ins/del | |||||||||||||
II | 37 | 101 | 37 | 101 | 47 | 105 | 1.00 | - | 0.89 | (0.51-1.55) | 1.15 | (0.67-1.97) | 0.84 |
ID and DD | 79 | 149 | 76 | 137 | 102 | 163 | 1.45 | (0.89-2.37) | 1.41 | (0.86-2.33) | 1.55 | (0.96-2.51) | |
PXR rs1523127 | |||||||||||||
AA | 33 | 94 | 42 | 76 | 52 | 87 | 1.00 | - | 1.37 | (0.77-2.47) | 1.55 | (0.89-2.70) | 0.08 |
AC and CC | 83 | 156 | 71 | 162 | 97 | 181 | 1.49 | (0.90-2.45) | 1.15 | (0.69-1.91) | 1.38 | (0.84-2.28) | |
PXR rs2276707 | |||||||||||||
CC | 63 | 141 | 70 | 135 | 104 | 165 | 1.00 | - | 1.01 | (0.65-1.57) | 1.24 | (0.82-1.87) | 0.43 |
CT and TT | 53 | 109 | 43 | 103 | 45 | 103 | 1.06 | (0.66-1.68) | 0.89 | (0.54-1.47) | 0.93 | (0.57-1.51) | |
PXR rs6785049 | |||||||||||||
AA | 40 | 89 | 38 | 85 | 58 | 85 | 1.00 | - | 0.92 | (0.52-1.61) | 1.37 | (0.80-2.33) | 0.28 |
AG and GG | 76 | 161 | 75 | 153 | 91 | 183 | 1.06 | (0.65-1.72) | 1.00 | (0.61-1.63) | 1.04 | (0.64-1.67) | |
LXR rs1405655 | |||||||||||||
CC | 49 | 117 | 54 | 116 | 66 | 114 | 1.00 | - | 0.93 | (0.56-1.54) | 1.18 | (0.72-1.92) | 0.83 |
CT and TT | 67 | 133 | 59 | 122 | 83 | 154 | 1.07 | (0.66-1.72) | 1.01 | (0.62-1.64) | 1.11 | (0.71-1.74) | |
LXR rs2695121 | |||||||||||||
TT | 36 | 74 | 35 | 63 | 46 | 84 | 1.00 | - | 1.12 | (0.61-2.07) | 1.20 | (0.67-2.13) | 0.67 |
CT and CC | 80 | 176 | 78 | 175 | 103 | 184 | 0.98 | (0.59-1.63) | 0.85 | (0.51-1.42) | 1.03 | (0.63-1.70) | |