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Table 3 Univariate and multivariate analysis of DFI for IMLN recurrence

From: Internal mammary lymph node recurrence: rare but characteristic metastasis site in breast cancer

Factors

N

Univariate analysis

Multivariate analysis

  

Median (m)

p-value

HR

95% CI

p-value

Menopausal stastus

  

0.773

NS

   Premenopausal

55

33

    

   Postmenopausal

78

42

    

Primary tumor location

  

0.837

NS

   Areola and inner area

61

38

    

   Outer area

72

40

    

Tumor size(cm)

  

0.008*

0.5

0.4- 0.8

0.002*

   ≤2

42

49

    

   >2

91

33

    

Axillary lymph node

  

0.070

NS

   negative

62

43

    

   positive

71

33

    

TNM stage

  

0.390

NS

   I - II

104

38

    

   III

29

29

    

ER/PR status

  

0.020*

0.6

0.4- 0.9

0.006*

   Positive

78

50

    

   Negative

55

32

    

HER-2 status

  

0.193

NS

   Positive

29

26

    

   Negative

104

42

    

Adjuvant chemotherapy

  

0.113

NS

   Yes

124

36

    

   No

9

41

    

Adjuvant radiotherapy for T >5 cm

  

0.018*

0.9

0.6- 1.3

0.463

   Yes

3

56

    

   No

4

21

    

Adjuvant radiotherapy for ALN ≥4

  

0.949

NS

   Yes

20

29

    

   No

8

26

    
  1. * p < 0.05