Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

Table 1 Summary of xenograft characteristics

	Basal-like xenograft (MAS98.12)		Luminal-like xenograft (MAS98.06)
	Primary tumor	Xenograft	Primary tumor	Xenograft
Tumor grade	Grade III IDC	NA	Grade III IDC	NA
Lymph node status	No metastasis	NA	Metastasis to 12 of 25 nodes	NA
			No distant metastases
Differentiation	Poorly differentiated	Poorly differentiated	Well differentiated	Poorly differentiated
Hormone receptor status	ER-/PgR+**	ER-/PgR-	ER+/PgR+	ER+/PgR+
ERBB2 amplification*	Negative	Negative	Negative	Negative
Intrinsic molecular subtype	Basal-like	Basal-like	Luminal-like	Luminal-like
TP53 status	Wildtype	Mutated	Mutated	Mutated
Volume doubling time	NA	1-2 days	NA	7 days
Proliferation index (Ki67)	Missing	28%	Missing	35%

Summary of characteristics related to genotype and phenotype of the xenograft models
* Measured at the DNA level by array Comparative Genomic Hybridization (aCGH)
** The primary basal-like carcinoma had very weak cytoplasmic staining for PgR²⁹.

ISSN: 1471-2407