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Figure 4 | BMC Cancer

Figure 4

From: Development of a highly metastatic model that reveals a crucial role of fibronectin in lung cancer cell migration and invasion

Figure 4

Fibronectin promotes SPC-A-1sci cell invasion and metastasis. A, Representative phase-contrast images of SPC-A-1sci and SPC-A-1 cells 4 hours after seeded on fibronectin coated or uncoated plates in cell spreading assays. Magnification, 200×. B, Immunoblotting detection of fibronectin in SPC-A-1sci cells infected with shRNAs against fibronectin (shRNA-Fn1) or negative control (shRNA-NC) as indicated. β-actin was used as a loading control. C and D, Trans-well migration and invasion assays for SPC-A-1sci cells infected with shRNAs against fibronectin (shRNA-Fn1) or negative control (shRNA-NC) as indicated. All experiments were repeated thrice; Results are expressed as mean ± SD; *, P < 0.05.

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BMC Cancer

ISSN: 1471-2407

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