Table 3 Prognostic Value of Clinicopathological Factors, CEA, SNCG, and Combined CEA and SNCG on DFS and OS of 170 Patients with Colon Adenocarcinoma

Univariate analysis

   TNM stage (III/IV vs. I/II)

4.745 (2.873-7.837)

<0.0001

4.667 (2.827-7.704)

<0.0001

   Depth of invasion(pT3 vs. pT1, T2)

3.539 (1.489-8.410)

0.004

3.507 (1.476-8.331)

0.004

   Differentiation (PD vs. WD, MD)

1.733 (1.130-2.658)

0.012

1.741 (1.144-2.649)

0.010

   LN metastasis(Positive vs. Negative)

3.701 (2.303-5.946)

<0.0001

3.593 (2.237-5.771)

<0.0001

   Intravascular embolus(Positive vs. Negative)

1.933 (1.202-3.106)

0.006

2.021 (1.257-3.248)

0.004

   CEA (Positive vs. Negative)

2.761 (1.739-4.383)

<0.0001

2.776 (1.750-4.405)

<0.0001

   SNCG (Positive vs. Negative)

2.146 (1.367-3.368)

0.001

2.121 (1.351-3.331)

0.001

   SNCG/CEA (either positive vs. both negative)

3.756 (2.097-6.729)

<0.0001

3.811 (2.127-6.830)

<0.0001

Multivariate analysis

   TNM stage (III/IV vs. I/II)

3.251 (1.209-8.748)

0.020

3.904 (1.447-10.536)

0.007

   Depth of invasion (pT3 vs. pT1, T2)

3.701 (1.449-9.450)

0.006

3.819 (1.488-9.805)

0.005

   Differentiation (PD vs. WD, MD)

2.116 (1.309-3.422)

0.002

2.075 (1.313-3.299)

0.002

   CEA (Positive vs. Negative)

2.440 (1.493-3.987)

<0.0001

2.639 (1.615-4.315)

<0.0001

   SNCG (Positive vs. Negative)

2.213 (1.391-3.520)

0.001

2.141 (1.349-3.401)

0.001

   SNCG/CEA (either positive vs. both negative)

3.517 (1.936-6.389)

<0.0001

3.645 (2.005-6.629)

<0.0001