Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

Table 3 Associations between the serum concentrations of tamoxifen, estrogens, FSH¹, and SHBG

Variables	Tamoxifen	4OHtam	4OHNDtam	NDtam	NDDtam	TamNox	SHBG
All (n = 90)	r	r	r	r	r	r	r
E2	0.295*	0.131	0.211	0.148	0.315**	0.232	-0.048
E1	0.297*	0.133	0.152	0.226	0.330**	0.292*	-0.002
E1S	0.254	0.119	0.118	0.247	0.194	0.284*	-0.445**
FSH	0.118	0.065	0.269*	0.134	0.031	0.178	0.095
SHBG	-0.027	0.034	0.088	0.000	0.048	0.103
Wt/Wt EM CYP2D6 (n = 51)
FSH	0.151	0.133	0.386*	0.148	0.133	0.259	0.224

¹FSH, Follicle Stimulating Hormone; SHBG, sex hormone binding globulin; 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-demethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N-oxide; r, coefficient; E2, estradiol; E1, estrone; E1S, estrone sulfate; Wt/Wt EM, wild type/wild type extensive metabolizer CYP2D6.
r and p values are derived from two-tailed Spearman correlation rank test. The p-values are given after Bonferroni correction for multiple (n = 5) comparisons within this data set, *p < 0.05, and **p < 0.01.

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