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Table 3 Tests for Heterogeneity of Treatment Effect According to the Clinicopathological Characteristics of the D1 and D3 Patients.

From: Does D3 surgery offer a better survival outcome compared to D1 surgery for gastric cancer? A result based on a hospital population of two decades as taking D2 surgery for reference

Subgroup

D1 surgery

D3 surgery

HR (95% CI)

P

 

No. of deaths/no. of patients

  

Total

150/187

137/191

1.407(1.113-1.779)

 

Age (years)

    

   ≤55

49/66

70/107

1.384(0.955-2.004)

0.086

   >55

101/121

67/84

1.242(0.911-1.693)

0.170

Sex

    

   Women

41/51

44/58

1.248(0.815-1.912)

0.309

   Men

109/136

93/133

1.463(1.103-1.939)

0.008*

Tumor size

    

   ≤5

91/125

74/113

1.401(1.028-1.910)

0.033*

   5-7

30/32

42/50

1.412(0.875-2.279)

0.158

   >7

29/30

21/28

1.917(1.075-3.419)

0.027*

Tumour site

    

   Upper stomach

40/44

37/42

1.116(0.707-1.762)

0.638

   Middle stomach

35/43

29/45

1.641(0.984-2.735)

0.058

   Lower stomach

64/88

59/90

1.482(1.038-2.117)

0.030*

   Whole stomach

11/12

12/14

1.574(0.685-3.618)

0.286

Gross appearance

    

   Borrmann types I

37/58

35/54

1.100(0.688-1.759)

0.691

   Borrmann types II

33/41

32/43

1.781(1.069-2.967)

0.027*

   Borrmann types III

66/73

56/77

1.685(1.175-2.416)

0.005*

   Borrmann types IV

14/15

14/17

1.708(0.810-3.600)

0.160

Tumour stage

    

   T1

29/41

24/44

1.723(0.992-2.992)

0.054

   T2

30/44

29/42

1.282(0.754-2.178)

0.359

   T3

79/89

71/92

1.431(1.037-1.977)

0.029*

   T4

12/13

13/13

1.071(0.485-2.365)

0.866

Clinical node status

    

   Negative

4/5

2/5

3.070(0.533-17.703)

0.209

   Positive

146/182

135/186

1.382(1.091-1.752)

0.007*

Lymph-node stage

    

   N0

50/69

42/69

1.781(1.168-2.718)

0.007*

   N1

64/75

60/81

1.504(1.055-2.145)

0.024*

   N2

24/30

19/24

1.116(0.609-2.044)

0.723

   N3

12/13

16/17

0.369(0.162-0.841)†

0.018*

Histological type

    

   Differentiated

62/99

49/82

1.143(0.761-1.563)

0.231

   Undifferentiated

62/99 50/88

49/82 56/109

1.047(0.773-1.732)

0.334

Joint organ removal

    

   None

127/160

104/157

1.703(1.309-2.217)

0.000*

   Pancreas or spleen

6/7

14/14

0.754(0.285-1.996)

0.569

   Liver or gall

9/11

9/9

0.532(0.200-1.415)

0.206

   Transverse colon

8/9

10/11

0.403(0.144-1.133)

0.085

Gastrectomy

    

   Total

20/22

26/29

1.259(0.697-2.274)

0.444

   Subtotal

130/165

111/162

1.495(1.156-1.932)

0.002*

Blood transfusion

    

   No

63/87

52/80

1.316(0.909-1.906)

0.146

   Yes

87/100

85/111

1.485(1.097-2.011)

0.011*

Blood loss

    

   ≤200

41/54

41/49

0.858(0.555-1.328)

0.493

   200-400

68/88

56/83

1.623(1.130-2.332)

0.009*

   >400

41/45

40/59

2.060(1.327-3.198)

0.001*

  1. The P values are for hazard ratios for death in the group assigned to D1 lymphadenectomy and the group assigned to D3 lymphadenectomy, with 95% confidence intervals.
  2. The surgery is better for D1 lymphadenectomy when the HR is <1; and is better for D3 lymphadenectomy when the HR is >1.
  3. †Significantly better for D1 lymphadenectomy.
  4. *Considered significant.
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BMC Cancer

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